Growth Differentiation Factor-15 in Chronic Heart Failure
نویسندگان
چکیده
منابع مشابه
Growth-Differentiation Factor-15 as Additional Prognostic Biomarkers in Heart Failure
Heart Failure (HF) remains to be a leading factor of cardiovascular morbidity and mortality. Although risk stratification of HF is promising prediction care, there are several controversies regarding choosing more optimal combinations of biomarkers and method (single versus serial measurements) of biomarker use in routine clinical practice. Growth differentiation factor-15 (GDF-15) is considere...
متن کاملThe novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction
AIMS Heart failure with normal ejection fraction (HFnEF) is an important clinical entity that remains incompletely understood. The novel biomarker growth differentiation factor 15 (GDF-15) is elevated in systolic heart failure (HFrEF) and is predictive of an adverse outcome. We investigated the clinical relevance of GDF-15 plasma levels in HFnEF. METHODS AND RESULTS A subgroup of patients fro...
متن کاملGDF 15 ( growth differentiation factor 15 )
The premature GDF/PDF/MIC-1 protein consists of 308 amino acids that contain a 29 amino acid signal peptide, a 167 amino acid propeptide, and a 112 amino acid mature protein. The mature protein is secreted as a homodimer linked by disulfide bonds and is released from the propeptide following intracellular cleavage at RXXR furine-like cleavage site. The mature peptide of GDF-1/MIC-1 contains two...
متن کاملGrowth Differentiation Factor 15 Predicts Chronic Liver Disease Severity
Background/Aims Growth differentiation factor 15 (GDF-15) belongs to the transforming growth factor-β superfamily. GDF-15 is emerging as a biomarker for several diseases. The aim of this study was to determine the clinical performances of GDF-15 for the prediction of liver fibrosis and severity in chronic liver disease. Methods The serum GDF-15 levels were examined via enzyme immunoassay in 1...
متن کاملPrognostic value of growth differentiation factor-15 in Chinese patients with heart failure: A prospective observational study.
BACKGROUND Growth differentiation factor-15 (GDF-15), a biomarker associated with remodeling, oxidative stress and inflammation, has been used to stratify heart failure (HF) patients. However, its prognostic value in Chinese HF patients is still unknown. METHODS GDF-15 levels were examined on admission in 272 consecutive HF patients in Beijing Hospital (a Chinese tertiary medical center) by a...
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ژورنال
عنوان ژورنال: JACC: Heart Failure
سال: 2018
ISSN: 2213-1779
DOI: 10.1016/j.jchf.2017.10.013